Int. J. One Health Vol.9 Article-9
Review Article
International Journal of One Health, 9(2): 122-133
https://doi.org/10.14202/IJOH.2023.122-133
Breaking the chains: Advancements in antiviral strategies to combat Nipah virus infections
2. S & T Fellows Program, Department of Science and Technology, Bicutan, Taguig City, 1634, Philippines.
Background and Aim: Nipah virus (NiV) is a highly pathogenic zoonotic virus that has caused several outbreaks with high fatality rates in humans and animals, thus, requiring a “One Health” approach. No specific treatment or vaccine is available for NiV infection, making the development of effective antiviral agents against this virus a critical research priority. In recent years, significant efforts have been made to identify and develop antiviral agents targeting the various stages of NiV pathogenesis. This review comprehensively discusses current research on antiviral agents against NiV. The promising results obtained with several compounds, including repurposed drugs, nucleoside analogs, phytochemicals, and multi-target inhibitors, are also highlighted. Developing effective antiviral agents against NiV remains a major challenge; however, recent advances in understanding the mechanisms of NiV pathogenesis and identifying potential targets for antiviral agents have provided hope for the future. Further research is required to identify and optimize antiviral agents with broad-spectrum activity against NiV and other related viruses.
Keywords: antiviral agents, Nipah virus, paramyxovirus, zoonotic pathogen.
Received: 22-05-2023 Accepted: 03-10-2023 Published online: 29-10-2023
Corresponding author: Fredmoore L. Orosco E-mail: orosco.fredmoore@gmail.com
DOI: 10.14202/IJOH.2023.122-133
Copyright: Orosco This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.