Article history: Received: 27-07-2018, Accepted: 27-08-2018, Published online: 23-09-2018
Corresponding author: Charity Ashe'osla Agada
E-mail: firstname.lastname@example.orgCitation: Agada CA, Mohammed J, Okoh AEJ, Ogugua JA (2018) Prevalence and risk factors associated with brucellosis among high-risk individuals in Lafia, Nasarawa state, Nigeria. Int J One Health 2018;4:45-51.
Background and Aim: Brucellosis caused by Brucella species is a zoonotic disease prevalent in Nigeria. Data on this disease in humans and its risk factors in Lafia, Nasarawa State, are lacking. This study was, therefore, designed to determine the prevalence of brucellosis and the risk factors among individuals most at risk in Lafia, Nasarawa State.
Materials and Methods: This study was conducted on high-risk individuals in the area using the Rose Bengal test (RBT) and questionnaire.
Results: Out of the 160 respondents tested for seropositivity to brucellosis, 10% (16/160) prevalence was recorded with the RBT. None of the factors evaluated was found to be significantly associated with the seroprevalence of brucellosis in the area. On the other hand, final logistic regression analysis found the knowledge of brucellosis to be significantly associated with the profession (OR=11.52; 95% CI=1.47-90.46; p=0.02) and age (OR=2.6; 95% CI=1.11-4.19; p=0.023). Furthermore, practices that expose to Brucella infection were found to be significantly associated with the site (OR=4.02; 95% CI=5.29- 333.33; p=0.000) and marital status (OR=2.44; 95% CI=1.03-5.75; p=0.042).
Conclusion: Brucellosis is prevalent among occupationally exposed individuals in Lafia. There should be continued surveillance for the disease and education of high-risk individuals in the area.
Keywords: age, brucellosis, humans, Lafia, prevalence, profession.
1. Baddour MM. Diagnosis of brucellosis in humans?: A review. J Vet Adv 2012;2:149-56.
2. World Health Organization. Brucellosis (Human). Excerpt from "WHO Recommended Standards and Strategies for Surveillance, Prevention and Control of Communicable Diseases. Geneva 27, Switzerland: WHO Headquarters; 2005. Available from: http://www.who.int/zoonoses/diseases/Brucellosissurveillance.pdf. [Last retrieved on 2017 May 05].
5. Shahid M, Basit A, Khan MA. Prevalence of brucellosis among the hospital patients of Peshawar, Khyber Pakhtunkhwa. J Inf Mol Biol 2014;2:19-21. [Crossref]
7. Ibironke AA, McCrindle CM, Fasina FO, Godfroid J. Evaluation of problems and possible solutions linked to the surveillance and control of bovine brucellosis in sub-Saharan Africa, with special emphasis on Nigeria. Vet Ital 2008;44:549-56. [PubMed]
8. Ariza J, Corredoira J, Pallares R, Viladrich PF, Rufi G, Pujol M, et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 1995;20:1241-9. [Crossref] [PubMed]
9. Muchaal P. Zoonoses of Dairy Cattle with Reference to Africa. Ottawa: Cities Feeding People International Development Research Centre (IDRC); 2001. p. 17-9. Available from: http: //www.ruaf.org. [Last accessed on 2014 May 20].
10. Onunkwo JI, Njoga EA, Nwanta JA, Shoyinka SV, Onyenwe IW, Eze JI. Serological survey of porcine brucellosis infection in South East, Nigeria. Niger Vet J 2011;32:60-2.
11. Smits HL, Basahi MA, Diaz R, Marrodan T, Douglas JT, Rocha A, et al. Development and evaluation of a rapid dipstick assay for serodiagnosis of acute human brucellosis. J Clin Microbiol 1999;37:4179-82. [PubMed] [PMC]
12. Demirdal T, Demirturk N. Laboratory-acquired brucellosis. Ann Acad Med 2001;37:86-7.
14. Megersa B, Biffa D, Niguse F, Rufael T, Asmare K, Skjerve E, et al. Cattle brucellosis in traditional livestock husbandry practice in Southern and Eastern Ethiopia, and its zoonotic implication. Acta Vet Scand 2011;53:24. [Crossref] [PubMed] [PMC]
15. Cadmus SI, Adesokan HK, Adedokun BO, Stack, JA. Seroprevalence of bovine brucellosis in trade cattle slaughtered in Ibadan, Nigeria, from 2004-2006. J S Afr Vet Assoc 2010;81:50-3. [Crossref] [PubMed]
17. Ofukwu AR, Yohanna CA, Abuh HA. Brucella infection among hospital patients in Makurdi, North Central Nigeria. Indian J Med Res Pharm Sci 2007;3:63-71.
18. Bertu WJ, Ajogi I, Bale JO, Kwaga JK, Ocholi RA. Sero-epidemiology of brucellosis in small ruminants in Plateau State, Nigeria. Afr J Micro Res 2010;4:1935-8.
19. Cadmus SI, Adesokan HK, Ajala OO, Odetokun WO, Perrett LL, Stack JA, et al. Seroprevalence of Brucella abortus and B. canis in household dogs in Southwestern Nigeria: A preliminary report. J S Afr Vet Assoc 2011;82:56-7. [Crossref] [PubMed]
20. Mai HM, Irons PC, Kabir J, Thompson PN. A large seroprevalence survey of brucellosis in cattle herds under diverse production systems in Northern Nigeria. BMC Vet Res 2012;8:144. [Crossref] [PubMed] [PMC]
21. Agada CA, Goden CP, Ogugua JA. Prevalence of bovine brucellosis and analysis of risk factors in resident cattle herds of Kanke local government area, Plateau State. Niger Vet J 2017;38:104-16.
22. Agada CA, Ogugua AJ, Anzaku EJ. Occurrence of brucellosis in small ruminants slaughtered in Lafia central abattoir, Nasarawa State, Nigeria. Sok J Vet Sci 2018;16:16-23. [Crossref]
23. Cadmus SI, Ijagbone IF, Oputa HE, Adesoko HK, Stack JA. Serological survey of brucellosis in livestock animals and workers in Ibadan, Nigeria. Afr J Biomed Res 2006;9:163-8.
24. Alton GG, Jones LM, Angus ED, Verger JM. Techniques for the Brucellosis Laboratory. Paris: Institute National De La Recherche Agronomique 147, Rue de I'Universite; 1988.
25. Aworh MK, Okolocha E, Kwaga J, Fasina F, Lazarus D, Suleman I, et al. Human brucellosis: Seroprevalence and associated exposure factors among abattoir workers in Abuja, Nigeria-2011. Pan Afr Med J 2013;8688:1-9. [Crossref]
26. Ishaya V, Ndumari W, Ankeli P, Bertu WJ. Isolation of Brucella abortus biotype1 in cattle with bi-lateral hygroma of the forelimb from Logo, Benue State Nigeria: A clinical case report. Int J Livestock Res 2012;2:223-9.
27. Nanven MA, Wungak SY, Gana BA, Nanven MB, Ngbede EO, Ibrahim M, et al. Seroprevalence of bovine brucellosis in Northern Plateau State, North Central Nigeria. Asian Pac J Trop Dis 2013;3:337-40. [Crossref]
28. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis 2006;6:91-9. [Crossref]
30. Mukhtar F, Kokab F. Brucella serology in abattoir workers. J Ayub Med Coll Abbottabad 2008;20:57-61. [PubMed]
32. Omer MM, Musa MT, Bakhiet MR, Perrett L. Brucellosis in camels, cattle and humans: Associations and evaluation of serological tests used for diagnosis of the disease in certain nomadic localities in Sudan. Rev Sci Tech 2010;29:663-9. [Crossref] [PubMed]
34. Ducrotoy MJ, Bertu WJ, Ocholi RA, Gusi AM, Bryssinckx W, Welburn S, et al. Brucellosis as an emerging threat in developing economies: Lessons from Nigeria. PLoS Negl Trop Dis 2014;8:e3008. [Crossref] [PubMed] [PMC]
35. Falade S. A case of possible brucellosis relapse in a veterinarian. Trop Vet 2002;20:226-30. [Crossref]
36. Serra J, Vi-as M. Laboratory diagnosis of brucellosis in a rural endemic area in Northeastern Spain. Int Microbiol 2004;7:53-8. [PubMed]
37. Adesokan HK, Alabi PI, Stack JA, Cadmus SI. Knowledge and practices related to bovine brucellosis transmission amongst livestock workers in Yewa, South-Western Nigeria. J S Afr Vet Assoc 2013;84:5. [Crossref] [PubMed]
38. Lopes LB, Nicolino R, Haddad JP. Brucellosis-risk factors and prevalence?: A review. Open Vet Sci J 2010;4:72-84. [Crossref]
39. Kechagia M, Mitka S, Papadogiannakis E, Kontos V, Koutis C. Molecular detection of Brucella spp. DNA in patients with manifestations compatible with emotional disorders. Open Infect Dis J 2011;5:8-12. [Crossref]
40. Ordu-a A, Almaraz A, Prado A, Gutierrez MP, Garcia-Pascual A, Due-as A, et al. Evaluation of an immunocapture-agglutination test (Brucellacapt) for serodiagnosis of human brucellosis. J Clin Microbiol 2000;38:4000-5.
41. Ismail TF, Smits H, Wasfy MO, Malone JL, Fadeel MA, Mahoney F, et al. Evaluation of dipstick serologic tests for diagnosis of brucellosis and typhoid fever in Egypt. J Clin Microbiol 2002;40:3509-11. [Crossref] [PubMed] [PMC]
42. Diaz R, Casanova A, Ariza J, Moriyon I. The rose Bengal test in human brucellosis: A neglected test for the diagnosis of a neglected disease. PLoS Negl Trop Dis 2011;5:e950. [Crossref] [PubMed] [PMC]
43. Smits HL, Abdoel TH, Solera J, Clavijo E, Diaz R. Immunochromatographic Brucella-specific immunoglobulin M and G lateral flow assays for rapid serodiagnosis of human brucellosis. Clin Diagn Lab Immunol 2003;10:1141-6. [PubMed] [PMC]
44. Mangen MJ, Otte J, Pfeiffer D, Chlonda P. Bovine Brucellosis in Sub-Saharan Africa?: Estimation of Sero-Prevalence and Impact on Meat and Milk Offtake Potential (Livestock policy) Discussion Paper; 2002.
45. ICONZ. The Rose Bengal Test (RBT) for the DIAGNOSIS of Brucellosis; 2011. Available from: http//www.icozafrica.org. [Last accessed on 2014 May 10].
46. Corbel MJ. Brucellosis in Humans and Animals. 20 Avenue Appia, 1211 Geneva 27, Switzerland: World Health Organization; 2006. Available from: http://www.who.int/csr/resources/publications/Brucellosis.pdf. [Last accessed on 2014 May 10].
47. Cernyseva MI, Knjazeva EN, Egorova LS. Study of the plate agglutination test with rose Bengal antigen for the diagnosis of human brucellosis. Bull World Health Organ 1977;55:669-74. [PubMed] [PMC]
48. Maichomo MW, McDermott JJ, Arimi SM, Gathura PB. Assessment of the Rose-Bengal plate test for the diagnosis of human brucellosis in health facilities in Narok district, Kenya. East Afr Med J 1998;75:219-22. [PubMed]49. Bayemi PH, Webb EC, Nsongka MV, Unger H, Njakoi H. Prevalence of Brucella abortus antibodies in serum of Holstein cattle in Cameroon. Trop Anim Health Prod 2009;41:141-4. [Crossref] [PubMed]