International Journal of One Health

Open access and peer reviewed journal on Human, Animal and Environmental health

ISSN (Online): 2455-8931

ISSN (Print): 2455-5673




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Review (Published online: 29-01-2018)

2. One health: The interface between veterinary and human health - Kshitiz Shrestha, Krishna Prasad Acharya and Sujan Shrestha

International Journal of One Health, 4: 8-14



  doi: 10.14202/IJOH.2018.8-14


Kshitiz Shrestha: Department of Veterinary Medicine, Kasetsart University, Faculty of Veterinary Medicine, Bangkok, Thailand.

Krishna Prasad Acharya: Regional Veterinary Laboratory, Pokhara, Nepal.

Sujan Shrestha: National Academy of Medical Science, Bir Hospital, Kathmandu, Nepal.


Received: 12-12-2017, Accepted: 08-01-2018, Published online: 29-01-2017


Corresponding author: Kshitiz Shrestha, e-mail:

Citation: Shrestha K, Acharya KP, Shrestha S. One health: The interface between veterinary and human health. Int J One Health 2018;4:8-14.


One Health is an emerging global key concept integrating human and animal health through international research and policy. The complex relationships between the human and animal have resulted in a human-animal-environment interface since prehistorical times. The people, animals, plants, and the environment are so intrinsically linked that prevention of risks and the mitigation of effects of crises that originate at the interface between humans, animals, and their environments can only improve health and wellbeing. The “One Health” approach has been successfully implemented in numerous projects around the world. The containment of pandemic threats such as avian influenza and severe acute respiratory syndrome within months of outbreak are few examples of successful applications of the One Health paradigm. The paper begins with a brief overview of the human-animal interface and continues with the socio-economic and public health impact caused by various zoonotic diseases such as Middle East respiratory syndrome, Influenza, and Ebola virus. This is followed by the role of “One Health” to deal the global problem by the global solution. It emphasizes the interdisciplinary collaboration, training for health professionals and institutional support to minimize global health threats due to infectious diseases. The broad definition of the concept is supposed to lead multiple interpretations that impede the effective implementation of One Health approach within veterinary profession, within the medical profession, by wildlife specialists and by environmentalists, while on the other side, it gives a value of interdisciplinary collaboration for reducing threats in human-animal-environment interface.

Keywords: emerging infectious diseases, one health, viral zoonoses.


1. Weiss RA, McMichael AJ. Social and environmental risk factors in the emergence of infectious diseases. Nat Med 2004;10:S70-6.
2. McMichael AJ. Environmental and social influences on emerging infectious diseases: Past, present and future. Philos Trans R Soc B Biol Sci 2004;359:1049-58.
PMid:15306389 PMCid:PMC1693387
3. Diamond J, Ford LE. Guns, germs, and steel: the fates of human societies. Perspect Biol Med 2000;43:609.
4. Mackenzie JS, Jeggo M, Daszak P, Richt JA. One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases. Heidelberg: Springer; 2013.
5. Morand S, McIntyre KM, Baylis M. Domesticated animals and human infectious diseases of zoonotic origins: Domestication time matters. Infect Genet Evol 2014;24:76-81.
6. Acha PN, Szyfres B. Zoonoses and Communicable Diseases Common to Man and Animals: Parasitic Zoonoses. Vol. 3. Washington, DC: Pan American Health Organisation; 2003.
7. World Health Organization. Zoonoses and the Human-Animal-Ecosystems Interface. Available from: [Last cited on 2015 Dec 05].
8. Hubálek Z. Emerging human infectious diseases: Anthroponoses, zoonoses, and sapronoses. Emerg Infect Dis 2003;9:403.
PMid:12643844 PMCid:PMC2958532
9. Harper K, Armelagos G. The changing disease-scape in the third epidemiological transition. Int J Environ Res Public Health 2010;7:675-97.
PMid:20616997 PMCid:PMC2872288
10. Morse SS. Factors in the emergence of infectious diseases. Emerg Infect Dis 1995;1:7-15.
PMid:8903148 PMCid:PMC2626828
11. Krieger N. Epidemiology and the web of causation: Has anyone seen the spider? Soc Sci Med 1994;39:887-903.
12. Gebreyes WA, Dupouy-Camet J, Newport MJ, Oliveira CJ, Schlesinger LS, Saif YM, et al. The global one health paradigm: Challenges and opportunities for tackling infectious diseases at the human, animal, and environment interface in low-resource settings. PLoS Negl Trop Dis 2014;8:e3257.
PMid:25393303 PMCid:PMC4230840
13. Taylor LH, Latham SM, Mark E. Risk factors for human disease emergence. Philosophical transactions of the royal society of London. Series B Biol Sci 2001;356:983-9.
PMid:11516376 PMCid:PMC1088493
14. World Health Organization. Strategic and Technical Meeting on Intensified Control of Neglected Tropical Diseases: A Renewed Effort to Combat Entrenched Communicable Diseases of the Poor. Berlin: Report of an International Workshop; 2006.
15. World Health Organization. The Control of Neglected Zoonotic Diseases: A Route to Poverty Alleviation: Report of a Joint WH; 2006.
16. World Health Organization. Intensified Control of Neglected Diseases: Report of an International Workshop. Berlin: WHO; 2004.
17. Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, Gittleman JL, et al. Global trends in emerging infectious diseases. Nature 2008;451:990-3.
18. Woolhouse ME, Gowtage-Sequeria S. Host range and emerging and reemerging pathogens. In: Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship-Workshop Summary, National Academies Press; 2006.
19. Taubenberger JK, Reid AH, Lourens RM, Wang R, Jin G, Fanning TG, et al. Characterization of the 1918 influenza virus polymerase genes. Nature 2005;437:889-93.
20. Fèvre E, Coleman P, Odiit M, Magona J, Welburn S, Woolhouse M, et al. The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda. Lancet 2001;358:625-8.
21. McNeil DG Jr. Zika Virus, a Mosquito-Borne Infection, May Threaten Brazil's Newborns. New York: New York Times; 2015.
22. Wolfe ND, Dunavan CP, Diamond J. Origins of major human infectious diseases. Nature 2007;447:279-83.
23. Morens DM, Folkers GK, Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature 2004;430:242-9.
24. Grace D, Mutua F, Ochungo P, Kruska R, Jones K, Brierley L, et al. Mapping of Poverty and Likely Zoonoses Hotspots; 2012.
25. WHO. Global Burden of Disease Report 2004 Update, 2008, Accessed; 2013.
26. Foundation TH. The U.S. Government and Global Emerging Infectious Disease Preparedness and Response; 2014. Available from: [Last accessed on 2015 Jun 28].
27. Hardy AT. The World Turned Upside Down: The Complex Partnership between China and Latin America. Vol. 34. Singapore : World Scientific; 2013.
28. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study. Lancet Infect Dis 2013;13:752-s61.
29. World Health Organization. Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Summary of Current Situation, Literature Update and Risk Assessment-as of 5 February 2015. World Health Organization; 2015.
30. World Health Organization. MERS-CoV in Republic of Korea at a Glance. World Health Organization; 2015
31. Gao F, Bailes E, Robertson DL, Chen YL, Rodenburg CM, Michael SF, et al. Origin of HIV-1 in the chimpanzee pan troglodytes troglodytes. Nature 1999;397:436-41.
32. Alexander DJ. An overview of the epidemiology of avian influenza. Vaccine 2007;25:5637-44.
33. Ungchusak K, Auewarakul P, Dowell SF, Kitphati R, Auwanit W, Puthavathana P, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 2005;352:333-40.
34. Osterholm MT. Preparing for the next pandemic. New Engl J Med 2005;352:1839-42.
35. Heymann DL, Rodier G. Global surveillance, national surveillance, and SARS. Emerg Infect Dis 2004;10:173-5.
PMid:15040346 PMCid:PMC3322938
36. Pawaiya R, Dhama K, Mahendran M, Tripathi B. Swine flu and the current influenza A (H1N1) pandemic in humans: A review. Indian J Vet Pathol 2009;33:1-17.
37. BBC. Swine Flu: Country by Country; 2015. Available from: [Last cited on 2015 Dec 11].
38. Capua I, Marangon S. Control of avian influenza in poultry. Emerging Infect Dis 2006;12:1319.
PMid:17073078 PMCid:PMC3294755
39. WHO Risk Assessment of Human Infections with Avian Influenza A(H7N9) Virus; 2015. Available from: [Last cited on 2015 Jun 28].
40. Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, Magassouba N, et al. Emergence of Zaire Ebola virus disease in Guinea. New Engl J Med 2014;371:1418-25.
41. Muyembe-Tamfum JJ, Mulangu S, Masumu J, Kayembe JM, Kemp A, Paweska JT, et al. Ebola virus outbreaks in Africa: Past and present. Onderstepoort J Vet Res 2012;79:6-13.
42. Brierley L, Vonhof MJ, Olival KJ, Daszak P, Jones KE. Quantifying global drivers of zoonotic bat viruses: A process-based perspective. Am Nat 2016;187:E53-64.
43. Team WE. Ebola virus disease in West Africa-the first 9 months of the epidemic and forward projections. N Engl J Med 2014;371:1481-95.
PMid:25244186 PMCid:PMC4235004
44. World Health Organization. Ebola Situation Report-3 June 2015. Geneva: WHO; 2015.
45. Chua K, Bellini WJ, Rota PA, Harcourt BH, Tamin A, Lam SK, et al. Nipah virus: A recently emergent deadly paramyxovirus. Science 2000;288:1432-5.
46. Mohd NM, Gan C, Ong B. Nipah virus infection of pigs in peninsular Malaysia. Rev Sci Tech 2000;19:160-5.
47. Chua KB. Nipah virus outbreak in Malaysia. J Clin Virol 2003;26:265-75.
48. Abram NJ, Gagan MK, McCulloch MT, Chappell J, Hantoro WS. Coral reef death during the 1997 Indian Ocean dipole linked to Indonesian wildfires. Science 2003;301:952-5.
49. Field HE. Bats and emerging zoonoses: Henipaviruses and SARS. Zoonoses Public Health 2009;56:278-84.
50. Daszak P, Plowright RK, Epstein JH, Pulliam J, Rahman SA. The emergence of Nipah and Hendra virus: Pathogen dynamics across a wildlife-livestock-human continuum. Disease Ecology: Community Structure and Pathogen Dynamics. Cary, NC: Oxford University Press; 2006. p. 186-201.
51. Hsu VP, Hossain MJ, Parashar UD, Ali MM, Ksiazek TG, Kuzmin I, et al. Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis 2004;10:2082-7.
PMid:15663842 PMCid:PMC3323384
52. Hankins DG, Rosekrans JA. Overview, prevention, and treatment of rabies. In: Mayo Clinic Proceedings. Elsevier; 2004.
53. Gongal G, Wright AE. Human rabies in the WHO Southeast Asia Region: Forward Steps for elimination. Adv Prev Med 2011;2011:383870.
PMid:21991437 PMCid:PMC3178116
54. Food and Agriculture Organization, World Organization for Animal Health. Contributing To One World, One Health: A Strategic Framework for Reducing Risks of Infectious Diseases at the Animal-Human-Ecosystems Interface; 2008.
55. Zinsstag J, Meisser A, Schelling E, Bonfoh B, Tanner M. From two medicines to one medicine to one health and beyond. In: 1st African One Health Conference, Johannesburg July; 2011.
56. One Health Commission. World Health Through Collaboration; 2015. Available from: [Last cited on 2015 Dec 12].
57. Mazet JA, Clifford DL, Coppolillo PB, Deolalikar AB, Erickson JD, Kazwala RR. A "one health" approach to address emerging zoonoses: The HALI project in Tanzania. PLoS Med 2009;6:e1000190.
PMid:20016689 PMCid:PMC2784942
58. Enserink M. Initiative aims to merge animal and human health science to benefit both. Science 2007;316:1553.
59. Wolking D. Health for Animals and Livelihood Improvement (HALI) Project; 2013. Available from: [Last cited on 2015 Dec 19].
60. Kilonzo B, Komba E. The current epidemiology and control of trypanosomiasis and other zoonoses in Tanzania. Cent Afr J Med 1993;39:10-20.
61. Gibbs EP. The evolution of one health: A decade of progress and challenges for the future. Vet Record 2014;174:85-91.
62. Time to eliminate rabies. Lancet 2015;386:2446.
63. Okello AL, Gibbs EP, Vandersmissen A, Welburn SC. One health and the neglected zoonoses: Turning rhetoric into reality. Vet Rec 2011;169:281-5.
64. Gibbs SE, Gibbs EP. The historical, present, and future role of veterinarians in one health. In: One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases. New York: Springer; 2013. p. 31-47.
65. Häsler B, Gilbert W, Jones BA, Pfeiffer DU, Rushton J, Otte MJ, et al. The economic value of one health in relation to the mitigation of zoonotic disease risks. In: One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases. New York: Springer; 2013. p. 127-51.
66. Atlas RM. One health: Its origins and future. In: One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases. New York: Springer; 2013. p. 1-13.
67. Rostal MK, Olival KJ, Loh EH, Karesh WB. Wildlife: The need to better understand the linkages. In: One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases. New York: Springer; 2013. p. 101-25.

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